Table 1 The previously reported AML cases with t(8;16)(p11.2;p13.3) and 1q duplication
| Sex | Age (years) | FAB type | Karyotype | 1q Bands | Outcome (years) | Last state | |
|---|---|---|---|---|---|---|---|
| Case 2 | F | 28 | M5 | 46,XX,t(8;16)(p11.2;p13.3), add(14)(p11.2)[11]/46,XX[9] | 1q32.1q44 |
CR after induction Relapsed 3 months later | Alive |
| Case 3 | F | 69 | M5 | 46,XX,t(8;16)(p11.2;p13.3)[2]/46,idem,add(3)(q?27)[18] | 1q32.1q44 | spontaneous regression | Died |
| Haferlach et al. | F | 39 | M5a | 45,XX,t(8;16)(p11;p13),der(10;13)(q10;q10)[10]/46,XX,der(7)t(1;7)(q21;q35),t(8;16)(p11;p13)[2]/46,XX[1] | 1q21 | NA | NA |
| Diab et al. | M | 14.5 | M4 | 46,XY,+1,del(1)(p22),t(8;16)(p11;p13),-10,der(14)t(10;14)(q11.2;p11.2)[8]/47,XY,del(1)(q11),+der(1)t(1;8)(p11;q11.2)x2,+i(5)(p10),-8,-10,der(14)t(10;14)(q11.2;p11.2),der(16)t(8;16) | Partial 1q gain | CR for 10.5 | Dead |
| Diab et al. | F | 14.2 | M4/5 | 5,XX,t(8;16)(p11;p13),-18,der(21)t(1;21)(q12;p13)[4]/46,XX[16] | 1q12 | CR for 5 | Alive |
| Diab et al. | F | 1.2 | M4 | 46,XX,t(8;16)(p11;p13)[3]/46,idem,der(10)t(1;10)(q11;p11)[5]/46,idem,add(7)(p21),der(10)t(1;10)(q11;p11)[2]/46,idem,add(7)(p21)[2]/46,XX[2} | 1q11 | CR for 0.6 | Died |
| Diab et al. | F | 14.1 | M4 | 46,XY,t(8;16)(p11;p13),der(14)t(1;14)(q31;p11)[20]* | 1q31 | CR for 11.5 | Alive |
| Diab et al. | F | 7.3 | M5 | 46,X,der(X)t(X;1)(q26;q23),t(8;16)(p11;p13),der(11)t(11;11)(p11;q13) | 1q23 | NA | NA |
| Xie et al. | M | 28 | M4 | 46,XY,der(3)t(3;8)(q27,q13),del(6)(p22),t(8;16)(p11.2;p13.3),del(10)(q21q25),add(13)(p11.2),del(16)(p12),del(20)(p11.2),del(20)(q11.2q13.3)[4]/46,idem,del(1)(p35p36.3),del(15)(q23),add(19)(p13.1)[2]/46,XY,t(8;16)(q27;q13),del(12)(q21q24.1),del(13)(q21q31),-16,der(19)t(1;19)(q32;p13.3),+mar[3]/46,XY,del(6)(p22),t(8;16)(p11.2;p13.3)[cp2]/46,XY[9] | 1q32 | CR for 7 months | Dead |
| Brown et al. | M | 71 | M4 | 47,X,der(Y)t(Y;1)(q12;q21), +6,t(8;16) (p11;p13)[6]/47,idem,del(13)(q3q3) [checked with CAD data] | 1q21 | No CR | Died 1 month after treatment |
| Brown et al. | F | 1.2 | M4 | 46,XX,t(8;16)(p11;p13)[3]/46,idem,der(10)t(1;10)(q11;p11)[5]/46,idem,add(7)(p21),der(10)t(1;10) (q11;p11) [2]/46,idem,add(7)(p21) [2]/46,XX [2] | 1q11 | Early remission after course 1. Relapsed at 5 months and 7 months after diagnosis | Died |