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Table 1 Cases of acute myeloid leukemia with sole trisomy 6 and their laboratory findings

From: Sole trisomy 6 an uncommon finding in pediatric acute myeloid leukemia, probably associated to bad prognosis

Case Diagnosis Karyotype Survival (months) Age (years) Sex WBC* Hb** PLT*** References Country
Adult cases
1 AML-NS NA 36 74 M NA NA NA Panani et al. [20] Greece
2 AML-M4 47,XX, + 6[8/18] 1 50 F NA NA NA Testa et al. [21] USA
3 AML-M5 47,XX,+6[58/58] 4 24 F NA NA NA Weh et al. [22] Germany
4 AML-M2 47,XX,+6[2/7] NA 81 M NA NA NA Chan et al. [23] Hong Kong
5 AML-M2 47,XX,+6[3/8] NA NA F NA NA NA Berger et al. [24] France
6 AML (M2) 47,XY,+6[15/21] > 1 55 M NA NA NA UKCCG [25] U.K.
7 AML (M5a) 47,XX,+6[17/17] > 15 55 M NA NA NA UKCCG [25] U.K.
8 AML-NS 47,XX,+6[2/?] 22 37 F NA NA NA UKCCG [25] U.K.
9 AML-M2 47,XX,+6[3/9]/46,XX[6/)9] 3 63 F 4.8 13.5 6 Jonveaux et al. [18] France
10 AML-M2 47,XX,+6[17/19]/46,XX[2/19] 1+ 28 F 4 11 53 Jonveaux et al. [18] France
11 AML-M4 47,XX,+6[19/30]/46,XX[11/30] 22 66 F 2.6 8.1 51 Mohamed et al. [11] USA
12 AML-M1 47,XX,+6[30/30] 1 74 M 29.4 9.3 26 Mohamed et al. [11] USA
13 AML-M1 47,XY,+6[20/20] 4 22 M 4.4 12.5 238 Mohamed et al. [11] USA
14 AML-M1 47,XY,+6[7/20]/46,XY[13/20] 10 40 M 86.5 11.1 63 Mohamed et al. [11] USA
15 AML-MRC 47,XX,+6[39/40]/46,XX[1/40] > 47 37 F 5.1 12.2 11 Mohamed et al. [11] USA
16 AML-NS 47,XX, +6[8/23]/46,XX[15/23] 27 41 F NA NA NA De Souza et al. [26] Brazil
17 AML-NS 47,XX,+6 NA NA F NA NA NA Kerndrup and Kjeldsen [27] Denmark
18 AML-NS 47,XX,+6 [11] NA 61 F NA NA NA Beyer et al. [28] Switzerland
19 AML-M1 47,XX,+6[20] 23 51 M 20.77 13.5 4 Yu et al. [4] South Korea
20 AML-M2 47,XX,+6[20] > 58 25 F 82.94 8 109 Yu et al. [4] South Korea
21 AML-M4 47,XX,+6[4/20]/46,XX,[16/20] 3 82 M 5.08 6.4 21 Yu et al. [4] South Korea
22 AML-M7 47,XX,+6[12/20]/46,XX[8/20] 1 21 F 56.3 5.4 85 Gupta et al. [10] India
23 AML-NS 47,XX,+6 1 50 F NR 8.5 11 Aydin et al. [29] Turkey
24 AML-M5 47,XY,+6 3 75 M 103.8 7.3 80 Manabe et al. [12] Japan
Pediatric cases
25 AML-NS 47,XY,+6 NA 11 M NA NA NA Philip et al. [13] Denmark
26 AML-NS 47,XX,+6[8] 27 8 F 99 NA NA Benedict et al. [14] USA
27 AML-(M3) 47,XY,+6 > 7 8 M NA NA NA UKCCG [25] U.K.
28 AML-M7 47,XX,+6[9/20]/46,XX[11/20] NA 1 M 16.4 7.6 6 McCullough et al. [15] Ireland
29 AML-NS 47,XX,+6 18 8 F NA NA NA Koh et al. [19] South Korea
30 AML-M4 47,XX,+6[12/15]/46,XX[3/15] 1 14 M 244 5.7 52 Present report  
  1. WBC *: White blood cells measured in 109/L; Hb **: Hemoglobin measured in g/dL; PLT ***: Platelets measured in 109/L; AML-NS: Acute Myeloid Leukemia non otherwise specified by FAB classification; NA: Not available data. U.K.: United Kingdom; USA: United States of America
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Molecular Cytogenetics

ISSN: 1755-8166

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